What is functional medicine and how is it different from traditional primary care?

Functional medicine looks beyond isolated symptoms to identify the root causes of fatigue, metabolic resistance, hormonal imbalance, systemic inflammation, and gut dysbiosis. Under Dr. Corina Ianculovici, DNP, FAAMFM, ABAAM-HP at Mirelle Institute in Manasquan, NJ, patients receive advanced predictive biomarker mapping, multi-system hormone analysis, and individualized cellular longevity protocols rather than broad population-average care.

What is DENSITY RF skin tightening?

DENSITY RF is an advanced non-surgical skin tightening platform delivering sequential Monopolar and Bipolar radiofrequency in every single pulse for immediate tissue contraction and deep volumetric collagen redensification across the face, neck, and body.

What is bioidentical hormone replacement therapy (BHRT)?

BHRT uses molecularly identical hormones to restore physiological levels of estrogen, progesterone, testosterone, and thyroid hormones. Evaluated through advanced functional endocrinology at Mirelle Institute, BHRT optimizes cognitive vitality, bone mineral architecture, cardiovascular resilience, and metabolic performance.

What are therapeutic peptides and how do they work in longevity medicine?

Peptides are short chains of amino acids that serve as targeted cellular signaling molecules. In medical longevity and restorative aesthetics, physician-formulated peptide protocols stimulate endogenous pathways for collagen induction, accelerated tissue repair, mitochondrial vitality, and metabolic body composition.

Clinician-curated medical-grade skincare collection featuring bioidentical estriol cream, GHK-Cu copper peptides, and clinical niacinamide serums on stone display at Mirelle Institute

Curated Clinical Skincare: Pharmaceutical-Grade Topicals, GHK-Cu, Bio-Identical Estriol & Barrier Science

Clinician-Curated Formulations by Dr. Corina Ianculovici, DNP, FAAMFM, ABAAM-HP

The Clinical Distinction in Topical Longevity

True cutaneous longevity requires precise cellular signaling. Over-the-counter beauty products often rely on superficial emollients and low concentrations of unstable actives that sit on the skin's surface without inducing biological repair.

At Mirelle Institute, our topical collection is selected, formulated, and prescribed under doctoral clinical oversight. Every product bridges in-office regenerative medicine, such as DENSITY RF, Total Skin Solution™, and autologous biostimulation, with daily home maintenance. We prioritize medical-grade bioavailability, liposomal delivery systems, bio-identical hormone support, and cellular signaling peptides to restore dermal density, reinforce epidermal barrier lipids, and optimize long-term tissue resilience.

Clinical Formulation Catalog

1. Compounded Estriol (0.05%), Niacinamide (4%), DMAE & HA (0.5%) Restorative Gel (30 gm)

Prescription Compounded Formulation for Estrogen-Deficient Skin, Barrier Integrity & Dermal Firming

Access Level: Prescription Only — Clinical Evaluation Required
Format: 30 gm Specialized Compounded Gel
The Clinical Science: A synergistic four-part compounded therapy formulated to reverse cutaneous hallmarks of estrogen deficiency, chronic moisture depletion, and microvascular aging:
Estriol (0.05%): Selectively targets cutaneous estrogen beta-receptors (ER-β), stimulating endogenous Type I and Type III collagen synthesis and improving dermal microcirculation without inducing systemic hormonal elevation.
Niacinamide (4%): Enhances epidermal ceramide and free fatty acid synthesis to repair a compromised skin barrier, accelerates cellular repair pathways (NAD+/NADH), calms facial erythema, and addresses stubborn hyperpigmentation.
DMAE (Dimethylaminoethanol): Promotes visible cutaneous tension and supports myofascial contraction along the jawline, submentum, and perioral zones.
Hyaluronic Acid (0.5%): Restores dermal hydrodynamic volume, deeply binds water molecules within the extracellular matrix, and creates a smooth, non-comedogenic gel reservoir.
Key Actives: Hyaluronic Acid 0.5%, Niacinamide 4%, Estriol 0.05%, DMAE in an elegant 30 gm transdermal gel vehicle.
Clinical Indications: Estrogen-deficient skin laxity, perimenopausal and postmenopausal dermal thinning, impaired barrier function, loss of lower-face definition, and superficial crepiness.
Patient Protocol: Compounded via licensed 503A accredited compounding pharmacies exclusively following diagnostic evaluation and medical history review under Dr. Corina Ianculovici.
Action: Schedule Clinical Evaluation | Call: 732-292-0100 | Text: 732-800-9448

2. Compounded GHK-Cu 1% Restorative Gel (Refrigerated, 30 gm)

Prescription Compounded Copper Tripeptide Therapy for Extracellular Matrix Remodeling & Cellular Repair

Access Level: Prescription Only — Clinical Evaluation Required
Format: 30 gm Compounded Topical Gel (Cold-Chain Stored / Refrigerated to Preserve Active Peptide Potency)
The Clinical Science: Standard commercial skincare often includes trace amounts of copper peptides (typically under 0.05%) in shelf-stable bases where oxidation can degrade peptide integrity. This clinical formulation utilizes a potent 1% concentration of pure GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) delivered in a specialized refrigerated transdermal gel vehicle:
Gene Expression & Tissue Remodeling: High-concentration GHK-Cu modulates human genes involved in biochemical remodeling, stimulating primary dermal fibroblasts to synthesize Type I and III collagen, elastin, and glycosaminoglycans (GAGs).
Downregulation of Inflammatory Cascades: Suppresses pro-inflammatory cytokines to minimize cellular senescent stress and accelerate deep dermal healing.
Antioxidant & Microvascular Support: Scavenges toxic lipid peroxidation byproducts and supports local cutaneous angiogenesis, accelerating tissue regeneration.
Cold-Chain Stability: Kept refrigerated at 2°C–8°C (36°F–46°F) to maintain bio-active peptide conformation and prevent hydrolytic degradation.
Key Actives: 1% Pure Copper Tripeptide-1 (GHK-Cu) in a 30 gm refrigerated vehicle.
Clinical Indications: Advanced skin laxity, compromised skin architecture, solar elastosis, profound textural roughness, and post-procedure recovery (DENSITY RF / Microneedling).
Patient Protocol: Compounded via certified 503A compounding facilities following diagnostic evaluation and clinical clearance with Dr. Corina Ianculovici. Requires domestic cold shipping or direct clinic pickup.
Action: Schedule Clinical Evaluation | Call: 732-292-0100 | Text: 732-800-9448

3. Clinical Niacinamide (Vitamin B3) & Lipid Barrier Restorative

Barrier-Strengthening & Anti-Inflammatory Cellular Complex

Access Level: Boutique Pickup & Priority Shipping
The Clinical Science: Clinical-strength niacinamide acts as a crucial co-factor (NAD+/NADH) in epidermal cellular metabolism. It accelerates endogenous ceramide, free fatty acid, and cholesterol synthesis within the stratum corneum, reinforcing barrier defenses, calming erythema, and regulating uneven melanin distribution.
Key Actives: 5% Clinical Niacinamide, Multi-Ceramide Complex (EOP, NP, AP), Phytosphingosine, Centella Asiatica.
Clinical Indications: Compromised skin barrier, rosacea-prone skin, persistent facial redness, enlarged pores.
Action: Reserve for In-Office Pickup or Order via Text: 732-800-9448

4. Compounded Soothing Botanical Recovery Complex

Specialized Post-Procedure Neuro-Calming & Epidermal Re-Epithelialization

Access Level: In-Office Procedure Option & Post-Treatment Care
The Clinical Science: Formulated as a compounded botanical shield designed to rapidly extinguish cutaneous thermal heat, mitigate acute erythema, and accelerate tissue recovery immediately following in-office energy interventions. Standardized therapeutic plant isolates downregulate inflammatory cascades (COX-2 and PGE2 pathways), protect compromised stratum corneum lipids, and provide a sterile, bio-compatible micro-environment for rapid re-epithelialization.
Key Actives: High-Purity Centella Asiatica Isolates (Standardized Asiaticoside & Madecassoside), Chamomile-Derived Bisabolol, Oat Beta-Glucan, Allantoin, and Biomimetic Squalane.
Clinical Indications: Administered immediately following DENSITY RF, medical microneedling, deep chemical peels, and laser resurfacing. Prescribed for post-treatment home barrier repair.
Action: Inquire During Your In-Office Procedure Consultation

5. AnteAGE MD® Biosignal Growth Factor & Cytokine System

Physiologically Balanced Stem Cell Signaling

Access Level: Boutique Pickup & Priority Shipping
The Clinical Science: Derived from human bone marrow mesenchymal stem cell conditioned media, AnteAGE MD delivers exact biosignaling proteins that guide tissue regeneration. These anti-inflammatory cytokines instruct fibroblasts to produce structural matrix proteins while minimizing post-procedure downtime.
Key Actives: Bone Marrow Mesenchymal Stem Cell Cytokines, Niacinamide, Carnosine, TGF-beta 3.
Clinical Indications: Structural collagen loss, advanced photoaging, procedural maintenance.
Action: Reserve for In-Office Pickup or Order via Text: 732-800-9448

6. CE + GTP Antioxidant Defense Serum

High-Potency Photoprotection & Free Radical Neutralization

Access Level: Boutique Pickup & Priority Shipping
The Clinical Science: A clinical-grade antioxidant shield combining stabilized 15% L-Ascorbic Acid with 90% active Green Tea Polyphenols and pure Vitamin E (Tocopherol). This formulation quenches reactive oxygen species (ROS), prevents ultraviolet-induced lipid peroxidation, and protects collagen integrity.
Key Actives: 15% L-Ascorbic Acid, Green Tea Polyphenols (GTP), Tocopherol, Ergothioneine.
Clinical Indications: Solar elastosis, environmental oxidative stress, post-inflammatory pigmentation, dull tone.
Action: Reserve for In-Office Pickup or Order via Text: 732-800-9448

7. Fractionated Hyaluronic Acid Intensive Serum

Multi-Depth Dermal Hydration & Surface Barrier Plumping

Access Level: Boutique Pickup & Priority Shipping
The Clinical Science: Combines multi-molecular weights of fractionated hyaluronic acid. Low-molecular fragments navigate beneath the surface to signal deep tissue hydration, while high-molecular fragments establish a protective, non-occlusive moisture barrier on the stratum corneum.
Key Actives: Multi-Fractionated Sodium Hyaluronate, Zinc PCA, Provitamin B5 (Panthenol).
Clinical Indications: Dehydration lines, rough texture, compromised hydration retention.
Action: Reserve for In-Office Pickup or Order via Text: 732-800-9448

Frequently Asked Questions

Q: Why do Estriol Gel and Refrigerated GHK-Cu 1% require a clinical consultation?

A: Because bio-identical estriol and concentrated 1% GHK-Cu signaling peptides directly interact with cellular receptors and induce deep extracellular matrix remodeling, they are regulated prescription therapies rather than over-the-counter cosmetics. Dr. Corina Ianculovici conducts a clinical evaluation to verify health history and ensure custom formulations are matched to your physiology before compounding.

Q: Why must the GHK-Cu 1% Gel remain refrigerated?

A: High-potency copper tripeptide (GHK-Cu) at a 1% concentration is biologically active and sensitive to hydrolytic degradation at room temperature. Cold-chain storage at 2°C–8°C (36°F–46°F) stabilizes the peptide's molecular conformation, guaranteeing peak signaling potency from the first application to the last.

Q: What are the benefits of estriol face cream for estrogen-deficient skin?

A: Estriol is a bio-identical estrogen with high affinity for local estrogen receptor beta (ER-β) in cutaneous tissue. When applied topically under clinical guidance, it helps increase collagen production, enhance skin elasticity, and restore dermal thickness in perimenopausal and postmenopausal skin without causing systemic hormone spikes.

Q: When is the Compounded Soothing Botanical Complex utilized?

A: The Compounded Soothing Botanical Complex is specifically applied immediately following in-office procedures such as DENSITY RF, microneedling, or chemical peels. Its clinical botanicals quickly reduce procedural erythema, soothe cutaneous heat sensations, and create a bio-protective shield during critical early tissue recovery.

Q: How can I purchase these clinical formulations?

A: Prescription compounds (#1 and #2) require a clinical evaluation with Dr. Corina Ianculovici prior to compounding. All other medical-grade formulations are available for direct in-office pickup at our Manasquan clinic or via priority shipping across New Jersey by contacting our team.