Clinician-Guided Peptide Therapy & Cellular Longevity Protocols

Targeted Biologic Signaling, Needle-Free Buccal Delivery & Mitochondrial Regeneration | Manasquan & Wall, NJ

Peptides do not override human physiology—they amplify cellular intelligence. As the body ages, endogenous signaling cascades decline, blunting growth hormone secretion, impairing mitochondrial ATP output, and slowing extracellular matrix repair. At Mirelle Institute, Dr. Corina Ianculovici (DNP, FAAMFM, ABAAM-HP, AGNP) integrates precision peptide medicine formulated to restore biological communication, accelerate physical recovery, and expand metabolic healthspan.
Rather than treating peptides as unregulated wellness trends, our protocols are strictly clinician-guided. We evaluate individual metabolic readiness, vascular integrity, and inflammatory terrain before introducing targeted injectable or breakthrough needle-free buccal therapies.

Clinical Philosophy & Diagnostic Qualification


The Mirelle Signaling Standard: Biological Readiness First

Cellular signaling is only as effective as the tissue receiving the message. Administering growth or regenerative peptides into a body experiencing uncontrolled systemic inflammation, insulin resistance, or sub-clinical endocrine imbalances yields suboptimal results and unnecessary physiological strain.
Prior to initiating any peptide therapy, candidates undergo multi-analyte diagnostic evaluation:
  • Metabolic & Glycemic Precision: Assessing fasting insulin, HOMA-IR, HbA1c, and advanced lipid fractions via The Metabolic Code®.
  • Endocrine & Neuroendocrine Balance: Evaluating baseline pituitary, thyroid, and adrenal axes alongside Hormone Optimization.
  • Systemic Inflammatory Markers: Screening hs-CRP, homocysteine, and vascular endothelial markers to confirm the cellular environment is receptive.
  • Extracellular Matrix (ECM) Quality: Gauging structural connective tissue integrity to optimize recovery.


Breakthrough Delivery - Precision Buccal (Needle-Free) & Injectable Options


Advanced Transmucosal & Subcutaneous Delivery
For patients seeking clinical alternatives to daily subcutaneous injections, Mirelle Institute provides advanced needle-free buccal (oromucosal) peptide formulations alongside traditional injectable options:
  • The Science of Buccal Absorption: Formulated using specialized permeation and mucoadhesive matrices, buccal delivery absorbs directly through the vascular oral mucosa into systemic circulation—bypassing first-pass gastrointestinal degradation and hepatic breakdown.
  • Injectable Gold-Standard Delivery: When pharmacokinetics demand precise peaks—such as nightly growth hormone pulse mimickers—subcutaneous micro-injections provide rapid, predictable bioavailability.
  • Clinical-Grade Sourcing: We partner exclusively with certified, compliant compounding pharmacies subject to rigorous analytical batch testing for purity, sterility, and sequence fidelity.


Primary Clinical Peptide Protocols


Precision Peptide Protocols at Mirelle Institute
1. Sermorelin Acetate (GHRH Analog) — Endogenous Pituitary Restoration
  • Mechanism: A bio-identical Growth Hormone-Releasing Hormone (GHRH) 1-29 analog that stimulates your pituitary gland to naturally synthesize and pulse its own Human Growth Hormone (HGH).
  • Clinical Benefits: Deepens slow-wave non-REM restorative sleep, stimulates collagen remodeling, enhances lipolysis (visceral fat reduction), and preserves lean muscle architecture without shutting down natural pituitary feedback loops.
2. BPC-157 (Body Protection Compound) — Connective Tissue & Gut Mucosa Repair
  • Mechanism: A cytoprotective pentadecapeptide that activates angiogenic pathways (VEGF signaling), accelerates fibroblast migration, and upregulates growth factor receptors.
  • Clinical Benefits: Supports rapid soft-tissue recovery (tendons, ligaments, joint capsules), calms intestinal permeability (leaky gut), and modulates localized inflammatory cascades.
3. GHK-Cu (Copper Tripeptide-1) — Extracellular Matrix & Skin Remodeling
  • Mechanism: A naturally occurring copper-binding complex essential for tissue remodeling, gene expression modulation, and extracellular matrix reorganization.
  • Clinical Benefits: Stimulates endogenous collagen and elastin synthesis, strengthens dermal thickness, accelerates post-procedure healing, and supports follicular microcirculation.
4. Thymosin Alpha-1 (Thymalfasin) — Immune Modulation & Resilience
  • Mechanism: An endogenous peptide originally isolated from thymus tissue that regulates T-cell differentiation, augments natural killer (NK) cell activity, and balances pro-inflammatory cytokine expression.
  • Clinical Benefits: Enhances systemic immune surveillance, dampens auto-inflammatory responses, and fortifies biological resilience during acute stress or chronic illness.
5. PT-141 (Bremelanotide) — Neuroendocrine Desire & Intimate Signaling
  • Mechanism: A synthetic melanocortin receptor agonist that acts centrally within the central nervous system (hypothalamic signaling) rather than peripherally on vascular tone.
  • Clinical Benefits: Enhances libido, sexual desire, and neural arousal pathways in both women and men. Coordinated synergistically with regenerative therapies such as The P-Shot® and The O-Shot®.
6. Cellular Coenzymes & Detoxification: Buccal NAD⁺ & Glutathione
  • Mitochondrial NAD⁺: Direct fuel for sirtuins and mitochondrial ATP synthesis, supporting cellular repair, metabolic efficiency, and mental stamina.
  • Master Antioxidant Glutathione: Formulated for oromucosal absorption to neutralize intracellular oxidative stress, optimize hepatic phase II detox pathways, and safeguard cellular longevity.


Foundational Supplements & Skincare Synergies


Foundational Peptide Supplements & Topical Skincare
In addition to clinician-prescribed formulations, we offer integrated over-the-counter foundational support and medical-grade topicals:
  • Dietary Peptide Supplements via Healthgevity: Non-injectable oral supplements formulated to support foundational cellular recovery and metabolic health pathways prior to or alongside clinical therapy.
  • Dr. Ianculovici Rx™ Firming Peptide Face & Neck Cream: Clinical-grade topical therapy infused with bioactive peptides, barrier ceramides, and antioxidants to lift, firm, and support collagen elasticity in delicate tissues.
  • Prescription GHK-Cu Dermal Formulations: Compounded transdermal preparations to accelerate skin repair following Total Skin Solution™ RF Microneedling or laser resurfacing.

Foundational Peptide Supplements & Cellular Support

In Clinical Partnership with Healthgevity


Peptides do not override human physiology—they amplify cellular intelligence. At Mirelle Institute, we ensure the body's internal terrain is primed before initiating advanced signaling.


As part of our commitment to accessible longevity care, we partner with **Healthgevity** to provide physician-curated, non-injectable dietary supplements formulated to support cellular energy, tissue repair, and metabolic health pathways. These over-the-counter formulations serve as an ideal starting point for individuals seeking foundational support before or alongside clinician-guided therapies.


Explore Foundational Peptide Supplements via Healthgevity



Ready for Clinician-Guided Precision Peptide Therapy?

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f you are experiencing chronic fatigue, persistent soft-tissue injury, metabolic slowdown, or sleep disruption, a customized medical protocol may be indicated. 


Schedule a Comprehensive Metabolic & Longevity Evaluation


Cellular Synergy: Transdermal Peptide Formulations & Barrier Longevity

Extending Clinical Regenerative Signaling to Daily Topical Protocols

Systemic peptide therapies and regenerative procedures initiate vital repair cascades from within, but extracellular matrix restoration also requires direct, surface-level signaling. The dermal micro-environment demands targeted nourishment to sustain cellular turnover, reinforce the lipid bilayer, and shield newly synthesized collagen from daily oxidative stressors.

At Mirelle Institute, Dr. Corina Ianculovici formulates and curates physician-grade topical regimens engineered with concentrated bioactive tripeptides, stem-cell–derived cytokines, and molecularly fractionated hydration. Whether accelerating tissue remodeling following Total Skin Solution™ RF Microneedling or fortifying delicate face and neck architecture against hormonally driven thinning, these advanced transdermal formulations deliver biological continuity between in-office treatments and home care.


Luxury Medical-Grade Skincare

Proprietary Luxury Medical-Grade Skincare- Dr. Ianculovici Rx™


Dr. Ianculovici Rx™ is a curated line of luxury, medical-grade skincare formulated to work in harmony with your in-clinic treatments. These clinical formulations are designed to restore optimal moisture balance, strengthen the dermal barrier, and enhance cellular renewal—extending and amplifying the results of advanced aesthetic procedures. By supporting collagen integrity, improving skin resilience, and refining luminosity at the cellular level, Dr. Ianculovici Rx™ helps maintain a radiant, healthy complexion long after you leave the treatment room.


AnteAGE® MD Regenerative Skincare

AnteAGE® MD is an advanced, physician-dispensed regenerative skincare system powered by bone-marrow–derived growth factors and cytokines. Designed to support cellular communication and dermal repair, AnteAGE® MD enhances collagen production, improves skin texture, and accelerates recovery following aesthetic procedures. At Mirelle, AnteAGE® MD is strategically integrated into treatment plans to calm inflammation, restore skin vitality, and promote a smoother, firmer, more luminous complexion—making it an ideal complement to microneedling, laser, and regenerative therapies.

Prescription GHK-Cu Peptide Skincare

GHK-Cu (Copper Tripeptide-1) is a prescription regenerative peptide skincare formulations to support advanced skin repair and rejuvenation. Clinically studied for its role in collagen and elastin synthesis, extracellular matrix remodeling, and skin barrier restoration, GHK-Cu helps improve firmness, texture, and overall skin resilience. At Mirelle, prescription GHK-Cu skincare is used strategically to accelerate healing after procedures, reduce inflammation, and strengthen dermal integrity—resulting in smoother, healthier, and visibly revitalized skin with continued use.


Prescription Estriol Face Cream

Prescription estriol face cream is a bio-identical, clinician-guided therapy designed to address hormonally driven skin aging. Estriol supports collagen density, improves skin thickness, enhances hydration, and restores elasticity by activating estrogen receptors in the skin—without the systemic exposure associated with stronger estrogens. At Mirelle, estriol face cream is carefully prescribed to appropriate candidates to improve firmness, smooth fine lines, and revive radiance, making it especially beneficial for peri- and post-menopausal skin experiencing thinning, dryness, and loss of vitality.

Cellular Synergy: Transdermal Peptide Formulations & Barrier Longevity

Extending Clinical Regenerative Signaling to Daily Topical Protocols

Systemic peptide therapies and regenerative procedures initiate vital repair cascades from within, but extracellular matrix restoration also requires direct, surface-level signaling. The dermal micro-environment demands targeted nourishment to sustain cellular turnover, reinforce the lipid bilayer, and shield newly synthesized collagen from daily oxidative stressors.

At Mirelle Institute, Dr. Corina Ianculovici formulates and curates physician-grade topical regimens engineered with concentrated bioactive tripeptides, stem-cell–derived cytokines, and molecularly fractionated hydration. Whether accelerating tissue remodeling following Total Skin Solution™ RF Microneedling or fortifying delicate face and neck architecture against hormonally driven thinning, these advanced transdermal formulations deliver biological continuity between in-office treatments and home care.

Dr. Ianculovici Rx™ Clinical Skincare

Medical-Grade Formulations for Cellular Renewal, Barrier Integrity & Post-Procedure Synergy

Clinical aesthetic procedures and systemic therapies trigger vital biological repair cascades, but long-term tissue quality depends on consistent, targeted at-home nourishment. Dr. Ianculovici Rx™ is a physician-formulated, clinical-grade skincare collection developed to optimize dermal architecture, restore the protective lipid barrier, and protect delicate tissues from environmental and oxidative stress.


Free of unnecessary fillers and formulated with pharmaceutical-grade actives, bio-fermented humectants, and targeted antioxidants, these medical-grade essentials amplify the results of regenerative in-clinic protocols—ensuring sustained hydration, collagen resilience, and luminous skin health between visits.

Dr. Ianculovici RX CE GTP Serum

CE +GTP SERUM

CE + GTP SERUM — $159

Dr. Ianculovici Rx™ Clinical Skincare


A clinical-grade, multi-pathway antioxidant concentrate formulated to neutralize environmental free radicals, inhibit melanogenesis, and support neocollagenesis. Powered by high-potency L-Ascorbic Acid, bio-available Glutathione, and concentrated Green Tea Polyphenols, this therapeutic elixir utilizes a sustained-release delivery matrix to maximize cellular uptake without triggering vascular irritation.


• Clinical Mechanism: Triple-network antioxidant defense that mitigates UV-induced photo-damage, evens irregular pigmentation, and preserves structural collagen integrity.

• Key Actives: Medical-Grade Vitamin C (L-Ascorbic Acid), Reduced L-Glutathione, Green Tea Polyphenols (GTP), Ergothioneine.

• Indicated For: Environmental photo-aging, dullness, post-inflammatory hyperpigmentation (PIH), and post-procedure cellular recovery.

• Regimen: Apply 4–5 drops each morning to thoroughly cleansed face, neck, and décolleté prior to hydrators and broad-spectrum sunscreen.

Dr. Ianculovici Rx Fractionated HA Serum

FRACTIONATED HYALURONIC ACID SERUM

FRACTIONATED HYALURONIC ACID SERUM — $95

Dr. Ianculovici Rx™ Clinical Skincare


A multi-weight, bio-compatible hydrator formulated with molecularly fractionated hyaluronic acid to penetrate multiple epidermal strata. Unlike high-molecular-weight hyaluronic acids that sit passively on the surface, this fractionated matrix draws water into deeper dermal layers to restore intracellular turgor, cushion cellular architecture, and reinforce the stratum corneum lipid barrier.


• Clinical Mechanism: Multi-depth humectant delivery that replenishes dermal water stores, stimulates endogenous hydration pathways, and accelerates re-epithelialization.

• Key Actives: Multi-Molecular Weight Fractionated Hyaluronic Acid (Sodium Hyaluronate), Zinc PCA, Copper PCA.

• Indicated For: Dehydrated tissue, compromised skin barriers, post-procedure recovery (microneedling, RF, chemical peels), and fine dynamic dehydration lines.

• Regimen: Apply 3–4 drops morning and evening to damp skin immediately after cleansing or antioxidant serums, following with a barrier-repair moisturizer.

Dr. Ianculovici Rx Firming Peptide Cream

FIRMING PEPTIDE FACE AND NECK CREAM

FIRMING PEPTIDE FACE & NECK CREAM — $125

Dr. Ianculovici Rx™ Clinical Skincare


A targeted, bio-stimulatory firming matrix engineered to reinforce the delicate micro-architecture of the cervical and facial dermis. Powered by bioactive signaling oligopeptides, barrier-identical ceramides, and micro-encapsulated niacinamide, this clinical formula counteracts gravity-induced laxity, replenishes lipid bilayers, and stimulates structural neocollagenesis.


• Clinical Mechanism: Stimulates extracellular matrix (ECM) redensification, inhibits elastase activity, and fortifies the dermo-epidermal junction (DEJ) to restore tissue firmness.

• Key Actives: Bioactive Signal Peptides, Ceramide NP/AP/EOP, Niacinamide (Vitamin B3), Edelweiss Botanical Meristem Cell Culture, Green Tea Polyphenols.

• Indicated For: Cervical skin laxity (crepey neck), submental horizontal banding, loss of jawline contour, and peri- or post-menopausal dermal thinning.

• Regimen: Apply an upward-sweeping layer morning and night across the neck, décolleté, and lower jawline following corrective serums.

FRACTIONATED HA+ NIACINAMIDE NOURISHING MOISTURIZER

FRACTIONATED HA + NIACINAMIDE NOURISHING MOISTURIZER — $99

Dr. Ianculovici Rx™ Clinical Skincare


A lipid-replenishing, barrier-restorative emulsion formulated to rebuild the stratum corneum and replenish depleted intracellular moisture reserves. Combining multi-molecular fractionated hyaluronic acid with therapeutic-grade niacinamide and essential ceramides, this clinical formulation optimizes epidermal hydration gradients while actively suppressing transepidermal water loss (TEWL) and sub-clinical inflammatory pathways.


• Clinical Mechanism: Dual-action barrier reinforcement that stimulates natural ceramide biosynthesis, modulates microvascular reactivity, and cushions dermal architecture.

• Key Actives: Fractionated Hyaluronic Acid (Sodium Hyaluronate), Niacinamide (Vitamin B3), Ceramide Bio-Complex, Squalane, Vitamin E.

• Indicated For: Barrier-compromised, chronically dry, or reactive skin; post-procedure soothing; and climate- or retinoid-induced xerosis.

• Regimen: Apply a pearl-sized amount morning and evening over the face, neck, and décolleté following corrective serums.

REBRIGHTALYZE ENHANCEMENT THERAPY

REBRIGHTALYZE ENHANCEMENT THERAPY — $125

Dr. Ianculovici Rx™ Clinical Skincare

(Optional 2% Hydroquinone Compounded Booster: +$25)


A targeted, multi-pathway pigment-regulation therapy engineered to inhibit melanogenesis, correct recalcitrant hyperpigmentation, and restore optical clarity. Delivered via single-use, medical-grade treatment pads, this clinical-strength formula combines botanical tyrosinase inhibitors with powerful polyphenols to disrupt melanin transfer without triggering rebound irritation or inflammatory flushing.


• Clinical Mechanism: Quadruple-inhibitor botanical complex that suppresses tyrosinase enzyme activity, accelerates melanin degradation, and calms localized vascular inflammation.

• Key Actives: Kojic Acid, Arbutin, Bearberry Extract (Arctostaphylos Uva-Ursi), Emblica Fruit Extract, Concentrated Green Tea Polyphenols, Evodiamine.

• Indicated For: Melasma, ultraviolet photo-damage, solar lentigines, post-inflammatory hyperpigmentation (PIH), and uneven skin tone (safe, alcohol-free, acetone-free formulation).

• Regimen: Sweep one pre-soaked pad gently over the face, neck, or targeted pigmented areas once daily in the evening, progressing to twice daily as tolerated. Always follow with broad-spectrum physical sunscreen during the day.

FIRMING RETINOL BODY LOTION

FIRMING RETINOL BODY LOTION — $125

Dr. Ianculovici Rx™ Clinical Skincare


An advanced, micro-encapsulated retinoid body emulsion formulated to stimulate cellular turnover, reverse solar elastosis, and redensify the extracellular matrix across extensive body surface areas. Engineered with time-released all-trans-retinol, lipid-replenishing ceramides, and concentrated polyphenols, this clinical formula accelerates epidermal renewal and promotes structural collagen synthesis while maintaining barrier integrity without excessive peeling or erythema.


• Clinical Mechanism: Controlled-release retinoid penetration that activates dermal fibroblast proliferation, accelerates micro-exfoliation of keratin debris, and refines dermal elasticity.

• Key Actives: Encapsulated All-Trans Retinol, Ceramide NP/AP, Leontopodium Alpinum (Edelweiss) Meristem Cell Culture, Green Tea Polyphenols, Biomimetic Phospholipids.

• Indicated For: Crepey skin texture, solar-damaged décolleté, laxity of the upper arms and thighs, post-weight-loss skin laxity, and generalized body xerosis.

• Regimen: Apply once daily in the evening over clean, dry body areas (arms, thighs, abdomen, décolletage), gently massaging until absorbed. Use daily broad-spectrum sun protection on exposed treated areas.

OIL-FREE SUN PROTECTION SPF 50+

OIL-FREE SUN PROTECTION SPF 50+ — $30

Dr. Ianculovici Rx™ Clinical Skincare


A high-performance, non-comedogenic physical/chemical hybrid photoprotective fluid formulated to shield vulnerable dermal matrices from photo-induced elastosis, DNA damage, and hyperpigmentation. Engineered with a sheer, micro-dispersed filter network and clinical antioxidants, it delivers broad-spectrum UVA/UVB defense with a lightweight, weightless matte finish that leaves zero white cast or occlusive residue.


• Clinical Mechanism: Multi-spectrum photoprotective shield that neutralizes free radicals, protects cellular DNA, and halts UV-mediated matrix metalloproteinase (collagen breakdown) activation.

• Key Actives: Broad-Spectrum UVA/UVB Protective Complex, Micro-Refined Zinc Oxide, Green Tea Polyphenols, Vitamin E (Tocopherol), Silky Mattifying Polymers.

• Indicated For: Post-procedure protection (microneedling, laser, chemical peeling), acne-prone or congested complexions, photosensitive skin, and daily anti-aging maintenance.

• Regimen: Apply liberally to the face, neck, and décolleté each morning 15 minutes prior to sun exposure as the final step in your clinical skincare regimen. Reapply every 2 hours or after 80 minutes of swimming or sweating.

GREEN TEA SOOTHING ANTIOXIDANT MIST

GREEN TEA SOOTHING ANTIOXIDANT MIST — $30

Dr. Ianculovici Rx™ Clinical Skincare


A multi-action botanical toning elixir formulated with pharmaceutical-grade green tea polyphenols to quench reactive erythema, neutralize environmental oxidative stress, and balance epidermal surface pH. Enriched with alcohol-free Hamamelis virginiana and bio-available trace minerals, this therapeutic mist calms irritated tissue and refines follicular ostia without stripping the delicate lipid barrier.


• Clinical Mechanism: Concentrated polyphenol defense that scavenges reactive oxygen species (ROS), down-regulates pro-inflammatory cytokines, and delivers immediate thermal relief.

• Key Actives: Ultra-Pure Green Tea Polyphenols (EGCG-rich), Alcohol-Free Witch Hazel, Micronutrient Sea Minerals, Glycerin, Ascorbyl Glucoside.

• Indicated For: Post-procedure cooling (laser resurfacing, microneedling, chemical peels), rosacea-prone or reactive complexions, sun-exposed tissue, and daily cellular toning.

• Regimen: Mist generously across the face, neck, and décolleté morning and evening following cleansing, or spritz throughout the day over bare skin or clinical skincare for instant soothing hydration.

PHYTO MULTI-CORRECTION SERUM

PHYTO MULTI-CORRECTION BOTANICAL SERUM — $65

Dr. Ianculovici Rx™ Clinical Skincare


A concentrated, non-comedogenic botanical corrective concentrate formulated to suppress neurovascular hyper-reactivity, neutralize reactive oxygen species (ROS), and accelerate barrier recovery. Engineered with therapeutic-grade plant bio-actives, targeted bioflavonoids, and soothing humectants, this lightweight elixir fortifies vulnerable dermal lipid bilayers, diminishes transient and chronic erythema, and protects compromised tissue against daily oxidative stress.


• Clinical Mechanism: Multi-pathway phyto-botanical complex that down-regulates pro-inflammatory vascular signaling, stabilizes capillary fragility, and restores dermal water homeostasis.

• Key Actives: Phyto-Corrective Botanical Bio-Complex, Bio-Fermented Botanical Extracts, Advanced Plant Bioflavonoids, Concentrated Antioxidants, Sodium Hyaluronate.

• Indicated For: Neuro-sensitive or reactive skin, erythematotelangiectatic rosacea, post-laser/microneedling inflammation, blotchy irregular complexions, and barrier-compromised tissue.

• Regimen: Dispense 3–4 drops onto cleansed face, neck, and décolleté morning and evening prior to heavier creams or hydrators. Safe for daily use following in-clinic aesthetic procedures.

GLY/SAL 10-2 CLEANSER

GLY/SAL 10–2 CLARIFYING CLEANSER — $50

Dr. Ianculovici Rx™ Clinical Skincare


A dual-acid, clinical-strength keratolytic wash engineered to decongest the pilosebaceous unit, normalize keratinization, and accelerate epidermal turnover. Combining ultra-pure 10% Glycolic Acid (AHA) with 2% USP Salicylic Acid (BHA), this therapeutic cleanser operates at multiple dermal depths—dissolving surface corneocyte cohesion while penetrating lipid-rich follicular channels to clear trapped sebum and cellular debris.


• Clinical Mechanism: Dual-depth chemical exfoliation that unblocks follicular ostia, mitigates acneiform eruptions, and refines irregular epidermal texture without stripping essential barrier lipids.

• Key Actives: 10% Ultra-Pure Glycolic Acid, 2% USP Salicylic Acid, Concentrated Green Tea Polyphenols, Zinc PCA.

• Indicated For: Acne vulgaris, comedonal congestion, post-inflammatory erythema/hyperpigmentation, folliculitis, and thickened photo-damaged skin.

• Regimen: Apply a moderate amount to wet skin and gently massage for 60 seconds. Rinse thoroughly with warm water. Use once or twice daily as tolerated, following with an antioxidant serum or barrier-repair moisturizer.

GLY/SAL 10-2 PADS

GLY/SAL 10–2 CLARIFYING PADS — $125

Dr. Ianculovici Rx™ Clinical Skincare


A targeted, medical-grade keratolytic exfoliation treatment engineered into convenient, pre-soaked textured pads. Formulated with a synergistic ratio of 10% ultra-pure Glycolic Acid (AHA) and 2% USP Salicylic Acid (BHA), this clinical system dissolves intercorneocyte cohesion while penetrating lipid-rich follicular channels to clear trapped sebum, eliminate cellular debris, and prevent comedone formation.


• Clinical Mechanism: Dual-action chemical exfoliation and mechanical debridement that unblocks pilosebaceous ducts, refines coarse texture, and suppresses inflammatory acne cascades without excessive dryness.

• Key Actives: 10% Ultra-Pure Glycolic Acid, 2% USP Salicylic Acid, Concentrated Green Tea Polyphenols, Witch Hazel (Hamamelis Virginiana).

• Indicated For: Active acne vulgaris, stubborn comedones (blackheads/whiteheads), post-inflammatory hyperpigmentation (PIH), facial/body folliculitis, and thickened keratolytic build-up.

• Regimen: Gently wipe one pad over clean, dry skin across the face, neck, chest, or back once daily in the evening, increasing to twice daily as tolerated. Do not rinse. Follow with corrective serums and daily broad-spectrum sun protection.

PLUMPING LIP TREATMENT WITH SPF 30

PLUMPING LIP TREATMENT WITH SPF 30 — $55

Dr. Ianculovici Rx™ Clinical Skincare


A clinician-formulated, multi-functional labial therapy engineered to stimulate micro-vascular volume, restore extracellular cushion, and provide broad-spectrum physical photoprotection to delicate vermilion tissue. Enriched with bioactive volume-enhancing signal peptides, multi-molecular weight fractionated hyaluronic acid, and broad-spectrum SPF 30 filters, this therapeutic balm smooths perioral rhytids, prevents UV-mediated collagen depletion, and supports youthful labial architecture without vascular irritation or chemical burning.


• Clinical Mechanism: Peptide-driven extracellular matrix (ECM) redensification combined with broad-spectrum photoprotection to shield vulnerable labial borders from photo-elastosis and volume loss.

• Key Actives: Bioactive Signal Oligopeptides, Fractionated Hyaluronic Acid (Sodium Hyaluronate), Broad-Spectrum UVA/UVB SPF 30 Complex, Ceramides, Biomimetic Conditioning Lipids.

• Indicated For: Thinning vermilion border, vertical perioral lines (smoker's/straw lines), photo-damaged labial tissue, post-lip filler maintenance, and chronic labial dehydration.

• Regimen: Apply generously to the lips 15 minutes before sun exposure. Reapply at least every 2 hours or as needed throughout the day for sustained hydration and volumetric support.

AGELESS ANTIOXIDANT CLEANSER

AGELESS ANTIOXIDANT CLEANSER — $42

Dr. Ianculovici Rx™ Clinical Skincare


A gentle, restorative conditioning cleanser formulated with pharmaceutical-grade botanical antioxidants and bio-compatible humectants to dissolve environmental pollutants, residual makeup, and oxidized sebum without disrupting the delicate stratum corneum. Engineered with concentrated green tea polyphenols, vitamin complexes, and calming botanical extracts, this non-stripping cleanser preserves skin surface pH, prevents barrier depletion, and prepares tissue for post-procedure or corrective serum uptake.


• Clinical Mechanism: Surfactant-optimized lipid cleansing that protects natural moisturizing factor (NMF), shields cell membranes against oxidative injury, and mitigates post-wash trans-epidermal water loss (TEWL).

• Key Actives: Medical-Grade Green Tea Polyphenols (EGCG-rich), Vitamin A (Retinyl Palmitate), Vitamin C (Ascorbyl Palmitate), Vitamin E, CoQ10, Panthenol (Pro-Vitamin B5).

• Indicated For: Sensitive, dry, mature, or post-procedure complexions (laser, RF microneedling, chemical peels) requiring barrier protection and anti-inflammatory comfort.

• Regimen: Apply a dime-sized amount to damp skin, gently massaging in circular motions across face and neck for 60 seconds. Rinse thoroughly with lukewarm water morning and evening.

Upneeq® - An Eye Lift in a Dropper

UPNEEQ® (OXYMETAZOLINE HYDROCHLORIDE OPHTHALMIC SOLUTION, 0.1%) — $150 / Box (30 Single-Use Vials)

Prescription Ophthalmic Elevation Therapy


A clinician-prescribed, once-daily ophthalmic solution engineered to elevate low-lying upper eyelids associated with acquired blepharoptosis. As the only FDA-approved non-surgical pharmaceutical therapy for acquired ptosis, Upneeq® restores optical aperture, expands the superior visual field, and provides a visible lift to tired, heavy-appearing eyes without surgical intervention or procedural downtime.


• Clinical Mechanism: Selective alpha-adrenergic receptor agonist that triggers controlled contraction of Müller’s superior tarsal muscle, elevating the upper palpebral margin within 15 minutes and sustaining elevation for up to 6–8 hours.

• Key Active: 0.1% Oxymetazoline Hydrochloride Ophthalmic Solution (preservative-free, single-use sterile vials).

• Indicated For: Acquired eyelid ptosis, age-related upper lid descent, visual aperture fatigue, asymmetric eyelid positioning, and aesthetic eye rejuvenation alongside [Neuromodulation Protocols](https://siteeditor.thryv.com/site/ff426ae1/neuromodulation-protocols?preview=true&nee=true&showOriginal=true&dm_checkSync=1&dm_try_mode=true&dm_device=tablet) or upper periorbital treatments.

• Regimen: Instill one drop into one or both affected eyes once daily. Individual sterile vials ensure precise, preservative-free dosing. Remove contact lenses prior to instillation and reinsert after 15 minutes.

CE +GTP SERUM

CE + GTP SERUM — $159

Dr. Ianculovici Rx™ Clinical Skincare


A clinical-grade, multi-pathway antioxidant concentrate formulated to neutralize environmental free radicals, inhibit melanogenesis, and support neocollagenesis. Powered by high-potency L-Ascorbic Acid, bio-available Glutathione, and concentrated Green Tea Polyphenols, this therapeutic elixir utilizes a sustained-release delivery matrix to maximize cellular uptake without triggering vascular irritation.


• Clinical Mechanism: Triple-network antioxidant defense that mitigates UV-induced photo-damage, evens irregular pigmentation, and preserves structural collagen integrity.

• Key Actives: Medical-Grade Vitamin C (L-Ascorbic Acid), Reduced L-Glutathione, Green Tea Polyphenols (GTP), Ergothioneine.

• Indicated For: Environmental photo-aging, dullness, post-inflammatory hyperpigmentation (PIH), and post-procedure cellular recovery.

• Regimen: Apply 4–5 drops each morning to thoroughly cleansed face, neck, and décolleté prior to hydrators and broad-spectrum sunscreen.

FRACTIONATED HYALURONIC ACID SERUM

FRACTIONATED HYALURONIC ACID SERUM — $95

Dr. Ianculovici Rx™ Clinical Skincare


A multi-weight, bio-compatible hydrator formulated with molecularly fractionated hyaluronic acid to penetrate multiple epidermal strata. Unlike high-molecular-weight hyaluronic acids that sit passively on the surface, this fractionated matrix draws water into deeper dermal layers to restore intracellular turgor, cushion cellular architecture, and reinforce the stratum corneum lipid barrier.


• Clinical Mechanism: Multi-depth humectant delivery that replenishes dermal water stores, stimulates endogenous hydration pathways, and accelerates re-epithelialization.

• Key Actives: Multi-Molecular Weight Fractionated Hyaluronic Acid (Sodium Hyaluronate), Zinc PCA, Copper PCA.

• Indicated For: Dehydrated tissue, compromised skin barriers, post-procedure recovery (microneedling, RF, chemical peels), and fine dynamic dehydration lines.

• Regimen: Apply 3–4 drops morning and evening to damp skin immediately after cleansing or antioxidant serums, following with a barrier-repair moisturizer.